{"id":226,"date":"2024-07-03T08:36:13","date_gmt":"2024-07-03T08:36:13","guid":{"rendered":"https:\/\/dev.ante-agency.com\/rbslab\/projects-2\/"},"modified":"2024-07-03T08:40:34","modified_gmt":"2024-07-03T08:40:34","slug":"projects-2","status":"publish","type":"page","link":"https:\/\/dev.ante-agency.com\/rbslab\/projects-2\/","title":{"rendered":"PROJECTS"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"226\" class=\"elementor elementor-226\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-51b6b8c2 elementor-hidden-mobile elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"51b6b8c2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5d0c3d21\" data-id=\"5d0c3d21\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3d6e1670 elementor-widget elementor-widget-spacer\" data-id=\"3d6e1670\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-column 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.elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7989d3f2 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7989d3f2\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-74471e18\" data-id=\"74471e18\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6ee09445 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"6ee09445\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7df999ae\" data-id=\"7df999ae\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ecd9b37 elementor-widget elementor-widget-image\" data-id=\"3ecd9b37\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"366\" src=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/01_Overview_HighRes-1024x468.jpg\" class=\"attachment-large size-large wp-image-154\" alt=\"\" srcset=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/01_Overview_HighRes-1024x468.jpg 1024w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/01_Overview_HighRes-300x137.jpg 300w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/01_Overview_HighRes-768x351.jpg 768w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/01_Overview_HighRes-1536x702.jpg 1536w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/01_Overview_HighRes-2048x935.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5d9f2cb7\" data-id=\"5d9f2cb7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2236ca34 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2236ca34\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-xl\" href=\"#Engineering_Microtools\" rel=\"nofollow\" engineer_microtools=\"\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Engineering Microrobots to Probe Cells and Tissues\u200b<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f10493c elementor-hidden-mobile elementor-widget elementor-widget-spacer\" data-id=\"7f10493c\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d6b0592 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"1d6b0592\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"#BAC\" rel=\"nofollow\" bacterial_cancer_therapy=\"\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Biohybrid Microrobots for Drug Delivery\u200b<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea0722f elementor-hidden-mobile elementor-widget elementor-widget-spacer\" data-id=\"ea0722f\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a643ed5 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2a643ed5\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"#NanoSensors\" rel=\"nofollow\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Micro-and Nanorobots for Disease Diagnostics\u200b<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9e9db5f elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"9e9db5f\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6eda3a23\" data-id=\"6eda3a23\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-41c1b12e elementor-widget__width-inherit elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"41c1b12e\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider 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.elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f2a48b6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f2a48b6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-376c3934\" data-id=\"376c3934\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-511cd51a elementor-widget elementor-widget-menu-anchor\" data-id=\"511cd51a\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\nbody.elementor-page .elementor-widget-menu-anchor{margin-bottom:0}<\/style>\t\t<div class=\"elementor-menu-anchor\" id=\"Engineering_Microtools\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b88f92 elementor-widget elementor-widget-heading\" data-id=\"5b88f92\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">Engineering Microrobots to Probe Cells and Tissues<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f60607e elementor-widget elementor-widget-text-editor\" data-id=\"f60607e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 26-06-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>The extracellular matrix (ECM) is an essential component of healthy tissue that provides structure and support. However, in maladies including cancer, it is now understood that the ECM can also play a harmful role in disease progression and that characteristics of the tumor micro-environment arise in part from mechanical interactions between malignant and non-transformed cells within the ECM.<\/p><p>Understanding the factors that contribute to tumor initiation, growth, and migration is crucial for developing effective diagnostic and therapeutic tools. While it is known that the ECM changes in tumors, resulting in a stiffer tissue, the lack of tools to precisely control the mechanical stimuli at the cellular level limits the study of how different mechanical cues impact tumor cell behavior and their potential implications for therapeutic strategies.<\/p><p>Our research in this field seeks to uncover new targets for treatment and mechanical cues that can be integrated into the design of diagnostic and therapeutic nanosystems. By using models that mimic tumors or simply the ECM, we are incorporating magnetic microrobots to apply controlled mechanical stimuli via custom magnetic instrumentation. This allows us to <a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2021\/lc\/d1lc00657f\" target=\"_blank\" rel=\"noopener\">infer local mechanical properties<\/a>, study cellular responses, such as proliferation, migration, and ECM reorganization, to better understand the influence of mechanical cues on tumor cell behavior.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-601015c2 elementor-widget elementor-widget-image\" data-id=\"601015c2\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"365\" src=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Microtools.jpg\" class=\"attachment-large size-large wp-image-155\" alt=\"\" srcset=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Microtools.jpg 930w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Microtools-300x137.jpg 300w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Microtools-768x350.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f78c854 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"f78c854\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-43e07bda\" data-id=\"43e07bda\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-19566e87 elementor-widget__width-inherit elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"19566e87\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-71d8a912 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"71d8a912\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-617f8b65\" data-id=\"617f8b65\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2434b896 elementor-widget elementor-widget-menu-anchor\" data-id=\"2434b896\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"BAC\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17c8bc1a elementor-widget elementor-widget-heading\" data-id=\"17c8bc1a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Biohybrid Microrobots for Drug Delivery<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7998cac3 elementor-widget elementor-widget-text-editor\" data-id=\"7998cac3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Targeted cancer therapy has brought new clinical approaches to the forefront, including the use of antibodies, small molecules, anti-angiogenics, and antivirals. However, these strategies are limited by the challenges of tumor accumulation and penetration.<\/p><p>Recently, synthetic biology has revitalized the idea of using living organisms to fight cancer. For instance, some bacteria can naturally accumulate in tumors, and can be engineered to induce local cytotoxicity while remaining harmless to the host. Clinical trials have demonstrated the safety and tolerance of strains such as E. coli and S. typhimurium for cancer therapy. S. typhimurium was initially shown to combat tumors through the recruitment of the host immune system and competition with cancer cells for nutrients, and later through the engineered production of therapeutic cargo through simple genetic modifications.<\/p><p>Synthetic biology is now taking this approach a step further by using genetic circuits with sophisticated sensing and delivery capabilities to enable bacteria to self-regulate therapeutic cargo production in response to tumor-specific stimuli.<\/p><p>Despite these exciting advances, there are still challenges in engineering bacteria for tumor therapy, such as\u00a0safety,\u00a0robust\u00a0colonisation via effective delivery of tolerable doses as well as improving penetration of tumors. To address these\u00a0hurdles, we are working on developing controllable, living biohybrid microrobots based on bacteria. This involves using either <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scirobotics.abo0665\" target=\"_blank\" rel=\"noopener\">magnetotactic bacteria<\/a>, which naturally produce magnetic particles, or functionalizing non-magnetic bacteria with magnetic nanomaterials for wireless magnetic control. These biohybrid microrobots are equipped with drug-filled nanoliposomes and\/or therapeutic genetic circuits and are controlled and tracked using custom-built magnetic instrumentation and algorithms. This approach represents a promising,\u00a0controllable, and biologically-based therapeutic platform for cancer treatment.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-470361c8 elementor-widget elementor-widget-image\" data-id=\"470361c8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"365\" src=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Bacteria-and-Cancer-1024x467.jpg\" class=\"attachment-large size-large wp-image-156\" alt=\"\" srcset=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Bacteria-and-Cancer-1024x467.jpg 1024w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Bacteria-and-Cancer-300x137.jpg 300w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Bacteria-and-Cancer-768x350.jpg 768w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Bacteria-and-Cancer-1536x701.jpg 1536w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Bacteria-and-Cancer.jpg 1765w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7e871092 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"7e871092\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-61a07bcb\" data-id=\"61a07bcb\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3457bf1d elementor-widget__width-inherit elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3457bf1d\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-645f1f1b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"645f1f1b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-79640d16\" data-id=\"79640d16\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2752d7bb elementor-widget elementor-widget-menu-anchor\" data-id=\"2752d7bb\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"NanoSensors\"><\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79b0a7d0 elementor-widget elementor-widget-heading\" data-id=\"79b0a7d0\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Micro-and Nanorobots for Disease Diagnostics<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-529f442b elementor-widget-mobile__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"529f442b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The field of personalized medicine is constantly evolving, and new diagnostic tools are needed to understand an individual patient&#8217;s disease state, inform clinical decision-making, and monitor therapeutic response. <a href=\"https:\/\/news.mit.edu\/2016\/nanosensors-determine-tumors-ability-to-remodel-tissue-0929\" target=\"_blank\" rel=\"noopener\">In previous work at MIT<\/a>, we developed a nanosensor that can identify tumor-specific enzymatic activity profiles, such as from proteases, a crucial class of enzymes, through localized sampling of the tumor microenvironment.<\/p><p>Our nanosensors are composed of thermosensitive liposomes containing functionalized biomarker substrates that are selectively unveiled at the target site by the heat dissipation of co-encapsulated magnetic nanoparticles (MNPs) in response to the application of an alternating magnetic field. A detection assay is then used to quantify the amount of cleaved marker substrates excreted in the urine, a reading that is directly correlated with specific protease activity in the tumor. The spatiotemporally controlled system has been used to measure in vivo tumor protease activity, revealing differences in enzymatic profiles between two mouse models of human colorectal cancer.<\/p><p>At RBSL, we continue to explore the potential of these and other concepts to develop micro- and nanosensors and mechanisms to control them and communicate diagnostic signals in a non-invasive and cost-efficient manner. For instance, we are designing <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202107143\" target=\"_blank\" rel=\"noopener\">protease-responsive ultrasound contrast agents (PRUCAs)<\/a> that can report protease activity through a change in the nonlinear backscattering signal of incoming acoustic waves. Our goal is to assess local protease activity by administering PRUCAs to patients and applying an ultrasound probe to a body area of interest. Additionally, we are developing nanosensors that detect protease activity, coupled with magnetic detection mechanisms, for in vivo use or as convenient benchtop readout systems.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-472e0ded elementor-widget elementor-widget-image\" data-id=\"472e0ded\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"365\" src=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Nanosensors-1024x467.jpg\" class=\"attachment-large size-large wp-image-157\" alt=\"\" srcset=\"https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Nanosensors-1024x467.jpg 1024w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Nanosensors-300x137.jpg 300w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Nanosensors-768x350.jpg 768w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Nanosensors-1536x701.jpg 1536w, https:\/\/dev.ante-agency.com\/rbslab\/wp-content\/uploads\/2024\/07\/Nanosensors.jpg 1765w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Engineering Microrobots to Probe Cells and Tissues\u200b Biohybrid Microrobots for Drug Delivery\u200b Micro-and Nanorobots for Disease Diagnostics\u200b Engineering Microrobots to Probe Cells and Tissues The extracellular matrix (ECM) is an essential component of healthy tissue that provides structure and support. However, in maladies including cancer, it is now understood that the ECM can also play [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-226","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/pages\/226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/comments?post=226"}],"version-history":[{"count":4,"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/pages\/226\/revisions"}],"predecessor-version":[{"id":372,"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/pages\/226\/revisions\/372"}],"wp:attachment":[{"href":"https:\/\/dev.ante-agency.com\/rbslab\/wp-json\/wp\/v2\/media?parent=226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}